Could blocking ACh in the gut affect other organs?

Yeah ACh isn’t just local it’s part of the parasympathetic system everywhere

Blocking it in the gut can definitely ripple into heart rate changes

Anticholinergic effects don’t stay isolated for long

You might see dry mouth or blurred vision too

ACh plays a role in vagus nerve signaling so it’s systemic

Heart rhythm can shift if muscarinic receptors get blocked broadly

The gut-brain axis is heavily cholinergic

Depending on the compound blood pressure might change

Central nervous system penetration makes a big difference

Bottom line ACh is everywhere blocking it locally can have whole-body effects

The body’s parasympathetic balance can shift toward sympathetic dominance

Some bronchodilators work this way affecting lungs too