How strong is the evidence that DHT metabolites have meaningful GABAergic, anxiolytic effects?

Hair loss fear has pushed many into long term DHT suppression

Secretagogues work best when the body is already primed for a pulse

Assay methods changed, numbers aren’t directly comparable.

Reference ranges shifted with population health decline overall.

Modern labs redefine normal based on current averages.

Reference ranges shifted, context often gets ignored.

Old labs used different calibration standards entirely.

Average dropped, so relative highs look higher now.

Sedentary lifestyles lowered baselines across populations worldwide today.

Sensitivity improvements altered what “normal” even means.

Population health changes skew modern reference ranges.

Sedentary lifestyles lowered baselines across populations worldwide today.

Old data came from healthier cohorts overall historically.

Free versus total DHT confusion adds misinterpretation.

Older data lacked mass-spec accuracy we have now.