If 98 ng/dL Was Average Then, Why Is 65 ng/dL ‘High’ Now?

Reference ranges shifted with population health decline overall.

Modern labs redefine normal based on current averages.

Average dropped, so relative highs look higher now.

Sedentary lifestyles lowered baselines across populations worldwide today.

Sedentary lifestyles lowered baselines across populations worldwide today.

Old data came from healthier cohorts overall historically.

Older data lacked mass-spec accuracy we have now.

Statistical reference ranges follow the bell curve only.

High now means uncommon, not historically optimal levels.

Medicine tracks populations, not evolutionary ideals anymore today.

Normalized dysfunction slowly redefines what’s considered high clinically.