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The MTHFR gene mutation mainly affects how your body processes folate and methylation pathways

Not all MTHFR mutations are equal C677T tends to have more impact than A1298C.

Elevated homocysteine is one of the main concerns linked with MTHFR variants

Many people have MTHFR mutations and never experience noticeable symptoms

Body strips cyanide and adds active methyl

Body activates it after proper absorption

Cells convert it into functional B12 forms

Supplementing with methylfolate instead of folic acid can be helpful for some individuals