How strong is the evidence that DHT metabolites have meaningful GABAergic, anxiolytic effects?

Bioavailability limits compound reaching effective concentrations in tissues.

Lab environments remove stress variables affecting real responses.

Exogenous GH offers precise control over dosing amounts.

Natural pulsatility reduces shutdown risk compared injections alone.

Whole body feedback loops alter biological effects significantly.

Safety profiles differ between cells and organisms greatly.

Both approaches useful depending goals physiology individual response.

Some stacks hit like 2x turbo, others just double your wallet drain.

Strong legs, strong brain? Bro, might be a thing.

Depends if they’re covering different pathways or just echoing each other.

Leg day = cardio for the neurons too.

Synergy if done right, redundancy if you’re just throwing vials.

Quad gains could mean blood flow gains upstairs.

Some combos feel magical, some feel placebo city.

Glutes firing, prefrontal cortex firing? Possibly.