HDACi influence which genes are active, impacting inflammation, aging and cellula

HDACi basically loosen chromatin, letting more genes get expressed

That shift in gene activity is why they affect inflammation pathways

The aging angle comes from epigenetic regulation not DNA changes

HDAC inhibition can restore youthful gene expression patterns.

Effects are highly dose and tissue dependent.

Chronic inflammation seems especially sensitive to HDAC modulation.

There’s a fine line between beneficial gene activation and toxicity

HDACi are powerful tools not gentle supplements

Epigenetic flexibility declines with age HDACi may counter that.

They highlight how environment can influence gene behavior without mutation

Gene expression changes can happen rapidly after exposure.