Why GH secretagogues fail when somatostatin tone stays high.?

Secretagogues can’t push GH if somatostatin is still holding the brake

You can press the gas GHRH/ghrelin all you want somatostatin is the handbrake

High stress, high cortisol high somatostatin tone muted GH pulse

Poor sleep keeps somatostatin elevated and blunts the response

Insulin spikes indirectly reinforce the inhibitory environment

Overtraining keeps the nervous system in a state that favors inhibition

If baseline GH pulsatility is low, secretagogues have little to amplify

Circadian disruption shifts the GH somatostatin balance the wrong way

Alcohol before bed elevates somatostatin tone overnight

Secretagogues work best when the body is already primed for a pulse